Lymphoid Structures | Immunology | Topic 7

This Section Include:

  • T Cell Differentiation: Positive and negative selection in the thymus.
  • Positive Selection: Survival of T cells with TCRs that bind self-MHCs.
  • Negative Selection: Elimination of T cells with high affinity for self-antigens.
  • Autoimmune Polyendocrine Syndrome 1: Symptoms and mnemonic "CHAR".
  • Differentiation Signals: Interleukins (ILs) guiding naive T cells' differentiation.
  • IL4 and IL33: Differentiate naive T cells into T helper 2 cells.
  • IL12 and Interferon Gamma: Transform naive T cells into T helper 1 cells.
  • Other ILs: Influence differentiation into T-R for 17 and T-FH cells.
  • T Helper 1 Cells: Function in enhancing macrophage killing of microbes.
  • Cytotoxic T Cells: Induce apoptosis in virus-infected and neoplastic cells.